Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Diffuse mastocytosis
Medically reviewed by Min Clinic Staff | Updated: January 2026
Diffuse mastocytosis: A form of mastocytosis in which the entire skin is thickened and leathery with generalized reddening and intense pruritus (itching) due to widespread infiltration of the skin with mast cells.
Treatment may include antihistamines, drugs to reduce stomach acid, migraine headache drugs for headache, and cromolyn for bowel symptoms.
Also called diffuse cutaneous mastocytosis.