Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.

Definition of Change, single base

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Change, single base: A change in which a single base in the DNA differs from the usual base at that position. These single base changes are also called SNPs or "snips."

Millions of SNP's have been cataloged in the human genome. Some SNPs such that which causes sickle cell are responsible for disease. Other SNPs are normal variations in the genome.

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