Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.

Definition of Annotation, genome

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Annotation, genome: The process of identifying the locations and the coding regions of genes in a genome and determining what those genes do. An annotation (irrespective of the context) is a note added by way of explanation or commentary. Once a genome is sequenced, it needs to be annotated to make sense of it.

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