Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.

Definition of Annotate

Medically reviewed by Min Clinic Staff | Updated: January 2026

Annotate: In genetics, to identify the locations and the coding regions of genes in a genome and determine what those genes do. To annotate (irrespective of the context) is to add a note by way of explanation or commentary. Once a genome is sequenced, it needs to be annotated to make sense of it.