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Definition of E2F3
Medically reviewed by Min Clinic Staff | Updated: January 2026
E2F3: E2F transcription factor 3.
E2F3 is a gene on chromosome 6p22 that is a member of the E2F family of transcription factors.
E2F3 may be a key gene in modulating the aggressivity of prostate cancer. E2F3 is present in a high proportion (67%) of prostate cancers. Men with prostate cancer exhibiting detectable E2F3 expression have poorer survival than those without detectable E2F3 expression.