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Definition of Demyelination

Medically reviewed by Min Clinic Staff | Updated: January 2026

Demyelination: A degenerative process that erodes away the myelin sheath that normally protects nerve fibers. Demyelination exposes these fibers and appears to cause problems in nerve impulse conduction that may affect many physical systems. Demyelinization is seen in a number of diseases, particularly multiple sclerosis.

Diagnosis is by functional observation and by testing for myelin protein in the blood.