Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Upper motor neuron
Medically reviewed by Min Clinic Staff | Updated: January 2026
Upper motor neuron: A neuron that starts in the motor cortex of the brain and terminates within the medulla (another part of the brain) or within the spinal cord. Damage to upper motor neurons can result in spasticity and exaggerated reflexes. There is no standard laboratory test for upper motor neuron disease.