Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Splenomegaly
Medically reviewed by Min Clinic Staff | Updated: January 2026
Splenomegaly: Abnormal enlargement of the spleen. Splenomegaly is a sign of an underlying condition, such as severe liver disease, leukemia, or mononucleosis. Patients with splenomegaly should avoid activities that risk trauma to the abdomen, including contact sports, because of risk of bleeding from the injured spleen.