Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of XXXXX syndrome
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
XXXXX syndrome: A chromosome disorder in females, caused by the presence of five X chromosomes rather than the usual two. It is characterized by decreased intelligence (IQ 20 to 75) and multiple malformations including upward-slanting palpebral fissures (eyeslits), heart defect, and small hands with incurving fifth fingers. It is the most severe extra-X syndrome in females. Also known as the penta-X syndrome.