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Definition of XXX syndrome

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

XXX syndrome: A chromosome condition present in 1 in 1000 females, due to the presence of three X chromosomes rather than the usual two. The condition is associated with increased height but no malformations. Intelligence ranges from above normal to mild retardation. The average IQ is 85 to 90. Learning problems may be helped by early special education. Also known as triple X; triplo-X.