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Definition of Wagner syndrome
Medically reviewed by Min Clinic Staff | Updated: January 2026
Wagner syndrome: a genetic condition caused by a mutation in the gene (CSPG2 on chromosome 5) encoding chondroitin sulfate proteoglycan-2, also known as versican. Versican is a substance present in the vitreous body of the eye. Symptoms and signs include changes in the vitreous body of the eye, retinal detachment, cataracts, and poor visual adaptation to dark. An association with cleft palate has been described. Studies suggest an irregular autosomal dominant pattern of inheritance.