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Definition of Spindle neuron
Medically reviewed by Min Clinic Staff | Updated: January 2026
Spindle neuron: A large neuron tapered at both ends that is only found in humans and great apes and so is thought to be a relatively recent evolutionary addition to the nervous system. Spindle neurons are confined to the anterior cingulate cortex, a region of the brain that plays a role in emotion, decision-making, and autonomic functions of the brain such as the regulation of the heart rate and blood pressure. Spindle neurons are typically lost in the course of Alzheimer disease.