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Definition of Ubiquitination
Medically reviewed by Min Clinic Staff | Updated: January 2026
Ubiquitination: The "kiss of death" process for a protein. In ubiquitination, a protein is inactivated by attaching ubiquitin to it. Ubiquitin is a small molecule. It acts as a tag that signals the protein-transport machinery to ferry the protein to the proteasome for degradation. For more information, see: Ubiquitin.