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Definition of Proteome
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Proteome: The complete set of proteins expressed and modified following their expression by the genome. The term "proteome" was coined from the PROTEin complement of the genOME in 1994 by Marc Wilkins, a graduate student at Macquarie University in Australia.
The analysis of the proteome is proteomics which Wilkins defined as "the study of proteins, how they're modified, when and where they're expressed, how they're involved in metabolic pathways and how they interact with one another."