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Definition of Selective Estrogen-Receptor Modulator (SERM)
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Selective Estrogen-Receptor Modulator (SERM): A "designer estrogen" which possesses some, but not all, of the actions of estrogen. For example, raloxifene (trade name EVISTA) is classified as a SERM because it prevents bone loss (like estrogen) and lowers serum cholesterol (like estrogen) but (unlike estrogen) does not stimulate the endometrial lining of the uterus.