Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.

Definition of Periventricular leukomalacia, cystic

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Periventricular leukomalacia, cystic: Softening of the white matter near the ventricles of the brain resulting in abnormal cysts. Cystic periventricular leukomalacia is a major problem in very premature infants.