Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Microcephalin 1
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Microcephalin 1: Mutation of this gene is responsible for an autosomal recessive form of primary microcephaly with no other malformations. Microcephalin 1 (MCPH1) is expressed in fetal brain in the developing forebrain and the walls of the lateral ventricles. Cells in this region divide to produce neurons that migrate to form the cerebral cortex. The MCPH1 gene is on chromosome 8 in region 8p23.