Educational Content: This article is for informational purposes only and does not constitute medical advice. Always consult a healthcare provider for diagnosis and treatment.
Definition of Osteolytic lesion
Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026
Osteolytic lesion: A "punched-out" area of severe bone loss. Osteolytic lesions are seen in metastatic lung and breast cancer and multiple myeloma and may cause bone pain, pathologic fractures (bones broken by disease), and hypercalcemia (high blood calcium).