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Definition of Lower motor neuron
Medically reviewed by Min Clinic Staff | Updated: January 2026
Lower motor neuron: A nerve cell that goes from the spinal cord to a muscle. The cell body of a lower motor neuron is in the spinal cord and its termination is in a skeletal muscle. The loss of lower motor neurons leads to weakness, twitching of muscle (fasciculation), and loss of muscle mass (muscle atrophy).