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Definition of Intermediate-grade lymphoma

Medically reviewed by Min Clinic Staff | Updated: January 2026

Intermediate-grade lymphoma: A lymphoma that is more aggressive (grows and spreads faster) than a low-grade lymphoma, but responds better to anticancer drugs. Intermediate-grade lymphomas include diffuse, small, cleaved cell lymphoma and diffuse, large, noncleaved cell lymphoma. Also called an aggressive lymphoma.