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Definition of Keratosis follicularis
Medically reviewed by Min Clinic Staff | Updated: January 2026
Keratosis follicularis: A genetic skin disease that is characterized by slowly progressive hardening of the skin (keratosis) around the hair follicles. This disorder is inherited in an autosomal dominant manner and is due to mutation in a gene called ATP2A2 on chromosome 12. Also known as Darier disease.