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Dromyl: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dromyl - General Information

Dromyl (Dramamine, Gravol and Vertirosan) is an over-the-counter drug used to prevent motion sickness. It is closely related to diphenhydramine HCl, or Benadryl. It is primarily a H1-antagonist, but also possesses an antimuscarinic effect.

 

Pharmacology of Dromyl

Dromyl is an antiemetics drug combination that contains diphenhydramine and theophylline. It is not effective in the treatment of nausea associated with cancer chemotherapy. Dromyl directly inhibits the stimulation of certain nerves in the brain and inner ear to suppress nausea, vomiting, dizziness, and vertigo.

 

Dromyl for patients

 

Dromyl Interactions

Dimenhydrinate may decrease emetic response to apomorphine.

 

Dromyl Contraindications

Dimenhydrinate may impede diagnosis of appendicitis and may obscure signs of overdose.

 

Additional information about Dromyl

Dromyl Indication

Used for treating vertigo, motion sickness, and nausea associated with pregnancy.

Mechanism Of Action
The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect.
Drug Interactions
Donepezil Possible antagonism of action
Food Interactions
Avoid alcohol.
Generic Name
Dimenhydrinate
Synonyms
Diphenhydramine Theoclate; Diphenhydrinate
Drug Category
Antiemetics; Histamine H1 Antagonists
Drug Type
Small Molecule; Approved
Other Brand Names containing Dimenhydrinate
Amosyt; Anautine; Andramine; Antemin; Aviomarin; Chloranautine; Diamarin; Dimate; Dimenest; Dimentabs; Dramalen; Dramamin; Dramarin; Dramilin; Dramyl; Dromyl; Eldodram; Gravinol; Gravol; Hydrinate; Menhydrinate; Neo-Navigan; Novamine; Permital; Reise-Engletten; Supremal; Teodramin; Travelin; Travelmin; Troversin; Vomex A; Xamamina;
Absorption
Well absorbed after oral administration.
Toxicity (Overdose)
Symptoms of overdose include delerium and hallucinations.
Protein Binding
98 to 99%.
Biotransformation
Hepatic (cytochrome P-450 system).
Half Life
1 to 4 hours
Dosage Forms of Dromyl
Solution Intravenous
Chemical IUPAC Name
2-benzhydryloxyethyl-dimethylazanium; 8-chloro-1,3-dimethyl-2-oxopurin-6-olate
Chemical Formula
C24H28ClN5O3
Organisms Affected
Humans and other mammals