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Doligur: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Doligur - General Information

A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Doligur shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem]

 

Pharmacology of Doligur

Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.

 

Doligur for patients

 

Doligur Interactions

No Information Provided.

 

Doligur Contraindications

None known.

 

Additional information about Doligur

Doligur Indication

For the symptomatic relief of patients with interstitial cystitis.

Mechanism Of Action
The mechanism of dimethyl sulfoxide's actions is not well understood. Doligur has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action.
Generic Name
Dimethyl sulfoxide
Synonyms
Diemthyl sulfoxide; Dimethyl sulfoxide BP; Dimethyl sulfur oxide; Dimethyl sulphoxide; Dimethyl sulpoxide; Dimexidum; Methylsulfinylmethane; Methyl sulfoxide; Sulfinylbis-methane; Sulfinylbismethane; Sulfinyldimethane
Drug Category
Analgesics, Non-Narcotic; Cryoprotective Agents; Free Radical Scavengers; Solvents
Drug Type
Small Molecule; Approved
Other Brand Names containing Dimethyl sulfoxide
Decap; Deltan; Demasorb; Demavet; Demeso; Demsodrox; Dermasorb; Dimexide; Dipirartril-tropico; Dolicur; Doligur; Domoso; Dromisol; Durasorb; Gamasol 90; Hyadur; Infiltrina; Kemsol; Rimso 50; Sclerosol; Somipront; Syntexan; Topsym;
Absorption
Readily and rapidly absorbed following administration by all routes and distributed throughout the body.
Toxicity (Overdose)
The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.
Biotransformation
Dimethyl sulfoxide is metabolized in man by oxidation to dimethyl sulfone or by reduction in dimethyl sulfide. Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces.
Dosage Forms of Doligur
Solution Topical
Chemical IUPAC Name
methylsulfinylmethane
Chemical Formula
C2H6OS
Organisms Affected
Humans and other mammals