Dolicur
Dolicur - General Information
A highly polar organic liquid, that is used widely as a chemical solvent. Because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals. It is also used to protect tissue during cryopreservation. Dolicur shows a range of pharmacological activity including analgesia and anti-inflammation. [PubChem]
Pharmacology of Dolicur
Dimethyl Sulfoxide may have anti-inflammatory, antioxidant and analgesic activities. Dimethyl Sulfoxide also readily penetrates cellular membranes. The membrane-penetrating ability of dimethyl sulfoxide may enhance diffusion of other substances through the skin. For this reason, mixtures of idoxuridine and dimethyl sulfoxide have been used for topical treatment of herpes zoster in the United Kingdom.
Dolicur for patients
Dolicur Interactions
No Information Provided.
Dolicur Contraindications
None known.
Additional information about Dolicur
Dolicur Indication: For the symptomatic relief of patients with interstitial cystitis.
Mechanism Of Action: The mechanism of dimethyl sulfoxide's actions is not well understood. Dolicur has demonstrated antioxidant activity in certain biological settings. For example, the cardiovascular protective effect of dimethyl sulfoxide in copper-deficient rats is thought to occur by an antioxidant mechanism. It is also thought that dimethyl sulfoxide's possible anti-inflammatory activity is due to antioxidant action.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dimethyl sulfoxide
Synonyms: Diemthyl sulfoxide; Dimethyl sulfoxide BP; Dimethyl sulfur oxide; Dimethyl sulphoxide; Dimethyl sulpoxide; Dimexidum; Methylsulfinylmethane; Methyl sulfoxide; Sulfinylbis-methane; Sulfinylbismethane; Sulfinyldimethane
Drug Category: Analgesics, Non-Narcotic; Cryoprotective Agents; Free Radical Scavengers; Solvents
Drug Type: Small Molecule; Approved
Other Brand Names containing Dimethyl sulfoxide: Decap; Deltan; Demasorb; Demavet; Demeso; Demsodrox; Dermasorb; Dimexide; Dipirartril-tropico; Dolicur; Doligur; Domoso; Dromisol; Durasorb; Gamasol 90; Hyadur; Infiltrina; Kemsol; Rimso 50; Sclerosol; Somipront; Syntexan; Topsym;
Absorption: Readily and rapidly absorbed following administration by all routes and distributed throughout the body.
Toxicity (Overdose): The oral LD50 of dimethyl sulfoxide in the dog is greater than 10 gm/kg. It is improbable that this dosage level could be obtained with intravesical instillation of dimethyl sulfoxide in the patient.
Protein Binding: Not Available
Biotransformation: Dimethyl sulfoxide is metabolized in man by oxidation to dimethyl sulfone or by reduction in dimethyl sulfide. Dimethyl sulfoxide and dimethyl sulfone are excreted in the urine and feces.
Half Life: Not Available
Dosage Forms of Dolicur: Solution Topical
Solution Intravesical
Chemical IUPAC Name: methylsulfinylmethane
Chemical Formula: C2H6OS
Dimethyl sulfoxide on Wikipedia: https://en.wikipedia.org/wiki/Dimethyl_sulfoxide
Organisms Affected: Humans and other mammals
