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Dibucain: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Dibucain - General Information

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)

 

Pharmacology of Dibucain

Dibucain is an amide-type local anesthetic, similar to lidocaine.

 

Additional information about Dibucain

Dibucain Indication: For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks. Mechanism Of Action: Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade. Drug Interactions: Methotrexate The NSAID increases the effect and toxicity of methotrexateLithium The NSAID increases serum levels of lithiumAcenocoumarol The NSAID increases the anticoagulant effect Food Interactions: Not Available Generic Name: Dibucaine Synonyms: Not Available Drug Category: Anesthetics, Local Drug Type: Small Molecule; Approved Other Brand Names containing Dibucaine: Cinchocaine; Cinchocaine HCL; Dermacaine; Dibucain; Dibucaine base; Dibucaine hydrochloride; Heavy Solution Nupercaine; Nupercainal; Nupercaine; Sovcaine; cinchocaine hydrochloride; Absorption: In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation. Toxicity (Overdose): Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest. Protein Binding: Not Available Biotransformation: Primarily hepatic. Half Life: Not Available Dosage Forms of Dibucain: Ointment Rectal Chemical IUPAC Name: 2-butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide Chemical Formula: C20H29N3O2 Dibucaine on Wikipedia: https://en.wikipedia.org/wiki/Dibucaine Organisms Affected: Humans and other mammals