Desmethyldopan

Desmethyldopan - General Information

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. [PubChem]

Pharmacology of Desmethyldopan

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Additional information about Desmethyldopan

Desmethyldopan Indication: Used for its antineoplastic properties.
Mechanism Of Action: After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Uracil mustard
Synonyms: Not Available
Drug Category: Antineoplastic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Uracil mustard: Aminouracil Mustard; Chlorethaminacil; Demethyldopan; Desmethyldopan; Haemanthamine; Nordopan; Uracil nitrogen mustard; Uracillost; Uracilmostaza; Uramustin; Uramustine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 5%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Desmethyldopan: Not Available
Chemical IUPAC Name: 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione
Chemical Formula: C8H11Cl2N3O2
Uracil mustard on Wikipedia: https://en.wikipedia.org/wiki/Uracil_mustard
Organisms Affected: Humans and other mammals