Medical Information Only: This medication is not sold on this site. The information provided is for reference purposes only. Please consult your local physician or pharmacist for treatment.

Damide: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Damide - General Information

A benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) so it is not clear that the mechanism is comparable. [PubChem]

 

Pharmacology of Damide

Damide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Damide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Damide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Damide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

 

Damide for patients

 

Damide Interactions

 

Damide Contraindications

Anuria. Known hypersensitivity to indapamide or to other sulfonamide-derived drugs.

 

Additional information about Damide

Damide Indication

For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.

Mechanism Of Action
Damide blocks the slow component of delayed rectifier potassium current (IKs) without altering the rapid component (IKr) or the inward rectifier current. Specifically it blocks or antagonizes the action the proteins KCNQ1 and KCNE1. Damide is also thought to stimulate the synthesis of the vasodilatory hypotensive prostaglandin PGE2.
Drug Interactions
Amantadine The diuretic increases the adverse effect of amantadine
Food Interactions
Take without regard to meals. Magnesium, potassium and zinc needs increased.
Generic Name
Indapamide
Synonyms
Indapamida [INN-Spanish]; Indapamidum [INN-Latin]
Drug Category
Antihypertensive Agents; Diuretics
Drug Type
Small Molecule; Approved
Other Brand Names containing Indapamide
Apo-Indapamide; Arifon; Bajaten; Cormil; Damide; Fludex; Gen-Indapamide; Idapamide; Indaflex; Indamol; Ipamix; Lozide; Lozol; Natrilix; Natrix; Noranat; Novo-Indapamide; Nu-Indapamide; Pressurai; Tandix; Tertensif; Veroxil;
Absorption
Rapidly absorbed from gastrointestinal tract.
Toxicity (Overdose)
Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Protein Binding
71-79%
Biotransformation
Primarily hepatic. Indapamide is an extensively metabolized drug with only about 7+ACU- of the total dose administered, recovered in the urine as unchanged drug during the first 48 hours after administration.
Half Life
14 hours (biphasic)
Dosage Forms of Damide
Tablet Oral
Chemical IUPAC Name
4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide
Chemical Formula
C16H16ClN3O3S
Organisms Affected
Humans and other mammals