Cyclapen-W: Full Drug Profile

Cyclapen-W - General Information

A cyclohexylamido analog of penicillanic acid. [PubChem]

Pharmacology of Cyclapen-W

Cyclapen-W, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclapen-W is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclapen-W has been replaced by newer penicillin treatments.

Additional information about Cyclapen-W

Cyclapen-W Indication

For the treatment of bacterial infections caused by susceptible organisms.

Mechanism Of Action

The bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclapen-W is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.

Generic Name

Cyclacillin

Synonyms

Ciclacilline [INN-French]; Ciclacillinum [INN-Latin]; Ciclacilina [INN-Spanish]; Aminocyclohexylpenicillin; Ciclacillin; Ciclacillum

Drug Category

Anti-Bacterial Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Cyclacillin

Bastcillin; Calthor; Citosarin; Cyclapen; Cyclapen-W; Orfilina; Syngacillin; Ultracillin; Vastcillin; Vipicil; Wyvital;

Absorption

Moderately absorbed.

Toxicity (Overdose)

Symptoms of overdose include severe diarrhea, nausea and vomiting.

Chemical IUPAC Name

(2S,5R,6R)-6-[(1-aminocyclohexanecarbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Chemical Formula

C15H23N3O4S

Organisms Affected

Enteric bacteria and other eubacteria