Cyclapen-W

Cyclapen-W - General Information

A cyclohexylamido analog of penicillanic acid. [PubChem]

Pharmacology of Cyclapen-W

Cyclapen-W, a penicillin, is a cyclohexylamido analog of penicillanic acid. Cyclapen-W is more resistant to beta-lactamase hydrolysis than ampicillin, is much better absorbed when given by mouth and, as a result, the levels reached in the blood and in the urine are considerably higher than those obtained with the same dose of ampicillin. Cyclapen-W has been replaced by newer penicillin treatments.

Additional information about Cyclapen-W

Cyclapen-W Indication: For the treatment of bacterial infections caused by susceptible organisms.
Mechanism Of Action: The bactericidal activity of cyclacillin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cyclapen-W is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cyclacillin
Synonyms: Ciclacilline [INN-French]; Ciclacillinum [INN-Latin]; Ciclacilina [INN-Spanish]; Aminocyclohexylpenicillin; Ciclacillin; Ciclacillum
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Cyclacillin: Bastcillin; Calthor; Citosarin; Cyclapen; Cyclapen-W; Orfilina; Syngacillin; Ultracillin; Vastcillin; Vipicil; Wyvital;
Absorption: Moderately absorbed.
Toxicity (Overdose): Symptoms of overdose include severe diarrhea, nausea and vomiting.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Cyclapen-W: Not Available
Chemical IUPAC Name: (2S,5R,6R)-6-[(1-aminocyclohexanecarbonyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C15H23N3O4S
Cyclacillin on Wikipedia: Not Available
Organisms Affected: Enteric bacteria and other eubacteria