Coactin
Coactin - General Information
Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus.
Pharmacology of Coactin
Coactin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Coactin is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Coactin, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Coactin is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.
Additional information about Coactin
Coactin Indication: Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species.
Mechanism Of Action: Coactin is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Amdinocillin
Synonyms: Amdinocillin mecillinam
Drug Category: Anti-Bacterial Agents; Penicillins; Anti-Infective Agents, Urinary
Drug Type: Small Molecule; Approved
Other Brand Names containing Amdinocillin: Coactin;
Absorption: Poorly absorbed if given orally.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Approximately 1 hour in patients with normal renal function. Increases to 3 to 6 hours in anephric patients.
Dosage Forms of Coactin: Not Available
Chemical IUPAC Name: (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
Chemical Formula: C15H23N3O3S
Amdinocillin on Wikipedia: Not Available
Organisms Affected: Gram-negative Bacteria