Coactin: Full Drug Profile

Coactin - General Information

Amidinopenicillanic acid derivative with broad spectrum antibacterial action. It is poorly absorbed if given orally and is used in urinary infections and typhus.

Pharmacology of Coactin

Coactin is a novel, semisynthetic penicillin effective against many gram-negative bacteria. The antibacterial activity of amdinocillin is derived from its ability to bind specifically and avidly to Penicillin Binding Protein-2 (PBP 2). Coactin is active alone against many gram-negative organisms. Pseudomonas and non-fermenting gram-negative bacteria, however, are usually resistant. Coactin, in combination with many beta-lactams, exhibits marked synergy against many enterobacteriaceae. No such synergy can be demonstrated for gram-positive organisms or pseudomonas species. Coactin is not beta-lactamase stable. Organisms which produce high levels of plasma-mediated beta-lactamase are resistant to the drug. Co-administration of probenecid results in markedly elevated plasma levels of amdinocillin and delays its excretion.

Additional information about Coactin

Coactin Indication

Used in the treatment of urinary tract infections caused by some strains of E. coli and klebsiella and enterobacter species.

Mechanism Of Action

Coactin is a stong and specific antagonist of Penicillin Binding Protein-2 (PBP 2).

Generic Name

Amdinocillin

Synonyms

Amdinocillin mecillinam

Drug Category

Anti-Bacterial Agents; Penicillins; Anti-Infective Agents, Urinary

Drug Type

Small Molecule; Approved

Other Brand Names containing Amdinocillin

Coactin;

Absorption

Poorly absorbed if given orally.

Half Life

Approximately 1 hour in patients with normal renal function. Increases to 3 to 6 hours in anephric patients.

Chemical IUPAC Name

(2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Chemical Formula

C15H23N3O3S

Organisms Affected

Gram-negative Bacteria