Clopixol

Clopixol - General Information

A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Pharmacology of Clopixol

Clopixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

Additional information about Clopixol

Clopixol Indication: For the management of the manifestations of schizophrenia.
Mechanism Of Action: Clopixol is a typical antipsychotic neuroleptic drug of the thioxanthene group. It mainly acts by antagonism of D1 and D2 dopamine receptors. Clopixol also has high affinity for alpha1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adrenergic receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Zuclopenthixol
Synonyms: Clopenthixol; Zuclopenthixolum [latin]; Zuclopentixol [spanish]
Drug Category: Antipsychotic Agents; Dopamine Antagonists
Drug Type: Small Molecule; Approved

Other Brand Names containing Zuclopenthixol: Clopixol;
Absorption: Not Available
Toxicity (Overdose): Although there have not been any cases of overdosage reported, the symptoms are likely to be somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, or hyper- or hypothermia.
Protein Binding: Approximately 98%.
Biotransformation: The metabolism of zuclopenthixol is mainly by sulphoxidation, side chain N-dealkylation and glucuronic acid conjugation. The metabolites are devoid of pharmacological activity.
Half Life: 20 hours (range 12-28 hours) for the tablet form, 19 days for the depot form.
Dosage Forms of Clopixol: Solution Intramuscular
Tablet Oral
Chemical IUPAC Name: 2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol
Chemical Formula: C22H25ClN2OS
Zuclopenthixol on Wikipedia: https://en.wikipedia.org/wiki/Zuclopenthixol
Organisms Affected: Humans and other mammals