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Clopixol: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Clopixol - General Information

A thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

 

Pharmacology of Clopixol

Clopixol is a thioxanthene with therapeutic actions similar to the phenothiazine antipsychotics. It is an antagonist at D1 and D2 dopamine receptors.

 

Additional information about Clopixol

Clopixol Indication: For the management of the manifestations of schizophrenia. Mechanism Of Action: Clopixol is a typical antipsychotic neuroleptic drug of the thioxanthene group. It mainly acts by antagonism of D1 and D2 dopamine receptors. Clopixol also has high affinity for alpha1-adrenergic and 5-HT2 receptors. It has weaker histamine H1 receptor blocking activity, and even lower affinity for muscarinic cholinergic and alpha2-adrenergic receptors. Drug Interactions: Not Available Food Interactions: Not Available Generic Name: Zuclopenthixol Synonyms: Clopenthixol; Zuclopenthixolum [latin]; Zuclopentixol [spanish] Drug Category: Antipsychotic Agents; Dopamine Antagonists Drug Type: Small Molecule; Approved Other Brand Names containing Zuclopenthixol: Clopixol; Absorption: Not Available Toxicity (Overdose): Although there have not been any cases of overdosage reported, the symptoms are likely to be somnolence, coma, extrapyramidal symptoms, convulsions, hypotension, shock, or hyper- or hypothermia. Protein Binding: Approximately 98%. Biotransformation: The metabolism of zuclopenthixol is mainly by sulphoxidation, side chain N-dealkylation and glucuronic acid conjugation. The metabolites are devoid of pharmacological activity. Half Life: 20 hours (range 12-28 hours) for the tablet form, 19 days for the depot form. Dosage Forms of Clopixol: Solution Intramuscular Tablet Oral Chemical IUPAC Name: 2-[4-[(3Z)-3-(2-chlorothioxanthen-9-ylidene)propyl]piperazin-1-yl]ethanol Chemical Formula: C22H25ClN2OS Zuclopenthixol on Wikipedia: https://en.wikipedia.org/wiki/Zuclopenthixol Organisms Affected: Humans and other mammals