Cefa

Cefa - General Information

Cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.

Pharmacology of Cefa

Cefa is a first-generation cephalosporin that has a wide spectrum of activity against gram-positive and gram-negative organisms. Cefa is more resistant to beta-lactamases than are the penicillins and so is effective against staphylococci, with the exception of methicillin-resistant staphylococci.

Additional information about Cefa

Cefa Indication: For treatment of infections caused by susceptible bacteria.
Mechanism Of Action: The bactericidal activity of cephapirin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Cephapirin
Synonyms: Cefapirin; Cefapirina [INN-Spanish]; Cefapirine [INN-French]; Cefapirinum [INN-Latin]; Cefaprin sodium; Cefaprin; Cephapirin Sodium; Cephapirine
Drug Category: Anti-Bacterial Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Cephapirin: Ambrocef; Cefa; Cefatrex; Cefatrexyl; Cefadyl;
Absorption: Not Available
Toxicity (Overdose): Rats exposed via the oral route to cephapirin displayed low acute toxicity (LD₅₀ = 14000 mg/kg). The most common adverse reactions are hypersensitivity reactions and alterations to liver function. Evidence of white blood cell disorders and anaemia were noted in some subjects.
Protein Binding: Not Available
Biotransformation: Major metabolite detected is desacetylcephapirin.
Half Life: Not Available
Dosage Forms of Cefa: Not Available
Chemical IUPAC Name: (6R,7R)-3-(acetyloxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C17H17N3O6S2
Cephapirin on Wikipedia: Not Available
Organisms Affected: Enteric bacteria and other eubacteria