Cebesine
Cebesine - General Information
Cebesine is the name of a local anesthetic, which is used especially in ophthalmology and otolaryngology. Cebesine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
Pharmacology of Cebesine
Cebesine is a local anaesthetic. It may be less irritating than tetracaine, and the onset and duration of action are similar to tetracaine.
Cebesine for patients
WARNINGS
NOT FOR INJECTION FOR TOPICAL OPHTHALMIC USE ONLY.
Prolonged use of a topical ocular anesthetic is not recommended. It may produce permanent corneal opacification with accompanying visual loss.
PRECAUTIONS
Fluress® (Fluorescein Sodium and Benoxinate Hydrochloride Ophthalmic Solution USP) should be used cautiously and sparingly in patients with known allergies, cardiac disease, or hyperthyroidism. The long-term toxicity is unknown; prolonged use may possibly delay wound healing. Although exceedingly rare with ophthalmic application of local anesthetics, systemic toxicity (manifested by central nervous system stimulation followed by depression) may occur.
Protection of the eye from irritating chemicals, foreign bodies and rubbing during the period of anesthesia is very important. Tonometers soaked in sterilizing or detergent solutions should be thoroughly rinsed with sterile distilled water prior to use. Patients should be advised to avoid touching the eye until the anesthesia has worn off.
Pregnancy:
Pregnancy Category C. Animal reproduction studies have not been conducted with Fluress®. It is also not known whether Fluress® can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Fluress® should be given to a pregnant woman only if clearly needed.
Nursing Mothers:
Caution should be exercised when Fluress® is administered to a nursing woman.
Cebesine Interactions
No reported significant interactions
Cebesine Contraindications
Known hypersensitivity to any component of this product.
Additional information about Cebesine
Cebesine Indication: Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.
Mechanism Of Action: Cebesine binds to sodium channel and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions. Depolarization of the neuronal membrane is inhibited thereby blocking the initiation and conduction of nerve impulses.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Oxybuprocaine
Synonyms: Oxybuprocaine HCL; Oxybuprocaine hydrochloride; Oxyriprocaine; Oxybucaine; Oxibuprokain; Oxibuprocainum; Oxbarukain; Dorsacaine hydrochloride; Benoxinate hydrochloride; Benoxinate HCL; Benoxinate
Drug Category: Anesthetics, Local
Drug Type: Small Molecule; Approved
Other Brand Names containing Oxybuprocaine: Benoxil; Cebesine; Conjucain; Conjuncain; Dorsacain; Dorsacaine; Fluress; Lacrimin; Minims Benoxinate; Novesin; Novesina; Novesine; Novesinol; Opulets Benoxinate; Prescaina;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Cebesine: Solution Ophthalmic
Chemical IUPAC Name: 2-diethylaminoethyl 4-amino-3-butoxybenzoate
Chemical Formula: C17H28N2O3
Oxybuprocaine on Wikipedia: https://en.wikipedia.org/wiki/Oxybuprocaine
Organisms Affected: Humans and other mammals
