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Candoxatrilat: Full Drug Profile
Medically reviewed by Min Clinic Staff | Updated: January 2026
Candoxatrilat - General Information
Candoxatrilat is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure.
Pharmacology of Candoxatrilat
Candoxatrilat is the orally-active prodrug of candoxatrilat (UK-73967), the active enantiomer of candoxatrilat (UK-69578), a potent neutral endopeptidase (NEP) inhibitor used in the treatment of chronic heart failure in man.
Additional information about Candoxatrilat
- Candoxatrilat Indication
For treatment of hypertension, improve exercise capacity in patients with CHF receiving angiotensin converting enzyme inhibition.
- Mechanism Of Action
- Neutral endopeptidase inhibitors such as Candoxatrilat have a dual mechanism of action. They inhibit two metalloprotease enzymes, neutral endopeptidase and ACE, resulting in an increased availability of natriuretic peptides that exhibit vasodilatory effects and, possibly, tissue protective effects.
- Generic Name
- Candoxatril
- Drug Category
- Prodrugs; Antihypertensive Agents
- Drug Type
- Small Molecule; Approved
- Other Brand Names containing Candoxatril
- Candoxatrilat;
- Chemical IUPAC Name
- 4-[[1-[(2S)-3-(2,3-dihydro-1H-inden-5-yloxy)-2-(2-methoxyethoxymethyl)-3-oxopropyl]cyclopentanecarbonyl]amino]cyclohexane-1-carboxylic acid
- Chemical Formula
- C29H41NO7
- Organisms Affected
- Humans and other mammals