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Cam-Ap-Es: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Cam-Ap-Es - General Information

An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Cam-Ap-Es inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.

 

Pharmacology of Cam-Ap-Es

Cam-Ap-Es is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Cam-Ap-Es are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance.

 

Additional information about Cam-Ap-Es

Cam-Ap-Es Indication: Foe the treatment of hypertension Mechanism Of Action: Cam-Ap-Es's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines. Drug Interactions: Dobutamine Increased arterial pressure Dopamine Increased arterial pressure Ephedrine Increased arterial pressure Ephedra Increased arterial pressure Epinephrine Increased arterial pressure Norepinephrine Increased arterial pressure Terbutaline Increased arterial pressure Salbutamol Increased arterial pressure Pseudoephedrine Increased arterial pressure Procaterol Increased arterial pressure Pirbuterol Increased arterial pressure Phenylpropanolamine Increased arterial pressure Phenylephrine Increased arterial pressure Orciprenaline Increased arterial pressure Methoxamine Increased arterial pressure Metaraminol Increased arterial pressure Mephentermine Increased arterial pressure Isoproterenol Increased arterial pressure Fenoterol Increased arterial pressure Food Interactions: Not Available Generic Name: Reserpine Synonyms: Not Available Drug Category: Antipsychotics; Antihypertensive Agents; Peripheral Adrenergic Inhibitors Drug Type: Small Molecule; Approved Other Brand Names containing Reserpine: Cam-Ap-Es; Demi-Regroton; Diupres-250; Diupres-500; Diutensen-R; Dralserp; Hiserpia; Hydrap-ES; Hydromox R; Hydroserpine Plus (R-H-H); Metatensin; Absorption: Not Available Toxicity (Overdose): Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg Protein Binding: 62% Biotransformation: Not Available Half Life: Not Available Dosage Forms of Cam-Ap-Es: Tablet Oral Chemical IUPAC Name: Not Available Chemical Formula: C33H40N2O9 Reserpine on Wikipedia: https://en.wikipedia.org/wiki/Reserpine Organisms Affected: Humans and other mammals