Budorm
Budorm - General Information
Budorm is a sedative and a hypnotic drug.
Pharmacology of Budorm
Budorm (also known as butobarbitone and butobarbital) belongs to a group of medicines called the barbiturates. It is thought to act on receptors in the brain (GABA receptors) causing the release of the chemical GABA. This chemical inhibits certain areas of the brain resulting in sleepiness.
Budorm for patients
Budorm Interactions
Interactions may occur with the following: adrenocorticoids (cortisone-like medicine), anticoagulants (blood thinners), carbamazepine, corticotropin (barbiturates may decrease the effects of these medicines), central nervous system (CNS) depressants (using these medicines with barbiturates may result in increased CNS depressant effects), divalproex sodium, valproic acid (using these medicines with barbiturates may change the amount of either medicine that you need to take), and oral contraceptives containing estrogens (barbiturates may decrease the effectiveness of these oral contraceptives, and you may need to change to a different type of birth control).
Budorm Contraindications
The following conditions may affect the use of barbiturates: alcohol abuse (or history of), history of/current drug abuse or dependence (dependence on barbiturates may develop), anemia (severe), asthma (history of), emphysema, or other chronic lung disease, diabetes mellitus (sugar diabetes), hyperactivity (in children), mental depression, overactive thyroid, porphyria (barbiturates may make the condition worse), kidney disease, liver disease (higher blood levels of barbiturates may result, increasing the chance of side effects), pain (barbiturates may cause unexpected excitement or mask important symptoms of more serious problems), underactive adrenal gland (barbiturates may interfere with the effects of other medicines needed for this condition).
Additional information about Budorm
Budorm Indication: For the treatment of insomnia.
Mechanism Of Action: Budorm binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. All of these effects are associated with marked decreases in GABA-sensitive neuronal calcium conductance (gCa). The net result of barbiturate action is acute potentiation of inhibitory GABAergic tone. Barbiturates also act through potent (if less well characterized) and direct inhibition of excitatory AMPA-type glutamate receptors, resulting in a profound suppression of glutamatergic neurotransmission.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Butethal
Synonyms: Butobarbital; 5-Butyl-5-ethyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 5-Butyl-5-ethylbarbituric acid; Butobarbitone; 5-Ethyl-5-butylbarbituric acid; 5-Ethyl-5-N-butylbarbituric acid; Butabarbitol; Butobarbitalum; Butobarbitural; Butyl,5-ethylbarbituric acid
Drug Category: Hypnotics and Sedatives; Barbiturates; Anti-anxiety Agents
Drug Type: Small Molecule; Illicit; Approved
Other Brand Names containing Butethal: Etoval; Hyperbutal; Longanoct; Meonal; Monodorm; Neonal; Sonerile; Soneryl; Budorm;
Absorption: Rapidly absorbed following oral administration.
Toxicity (Overdose): Signs of overdose include confusion (severe), decrease in or loss of reflexes, drowsiness (severe), fever, irritability (continuing), low body temperature, poor judgment, shortness of breath or slow or troubled breathing, slow heartbeat, slurred speech, staggering, trouble in sleeping, unusual movements of the eyes, weakness (severe).
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: 37 hours
Dosage Forms of Budorm: Not Available
Chemical IUPAC Name: 5-butyl-5-ethyl-1,3-diazinane-2,4,6-trione
Chemical Formula: C10H16N2O3
Butethal on Wikipedia: https://en.wikipedia.org/wiki/Butobarbital
Organisms Affected: Humans and other mammals
