Brantur: Full Drug Profile

Brantur - General Information

Brantur is a psychotropic drug which has proved to be effective in the treatment of various depressive states. Like most antidepressants minaprine antagonizes behavioral despair. Brantur is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain.

Pharmacology of Brantur

Brantur is an amino-phenylpyridazine antidepressant reported to be relatively free of cardiotoxicity, drowsiness, and weight gain. Similar to other antidepressant treatments, minaprine attenuates the beta-adrenergic receptor function. Studies have also shown that minaprine improves memory consolidation and that repeated drug administration leads to potentiation of this effect. Moreover, the effects of minaprine on memory consolidation are related to its dopaminergic action.

Additional information about Brantur

Brantur Indication

For the treatment of depression

Mechanism Of Action

Brantur binds to serotonin type 2 receptors and to dopamine D1 and D2 type receptors. It also binds to the serotonin reuptake pump. Therefore, minaprine blocks the reuptake of both dopamine and serotonin. It is also, to a slight degree, cholinomimetic. Thus it may exhibit both mood-brightening and nootropic properties.

Generic Name

Minaprine

Synonyms

Minaprine Hydrochloride; Minaprine Dihydrochloride; Minaprina [Inn-Spanish]; Minaprinum [Inn-Latin]

Drug Category

Antiparkinson Agents; Antidepressive Agents; Central Nervous System Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Minaprine

Brantur; Cantor;

Biotransformation

Hepatic. Cytochrome P4502D is responsible for the 4-hydroxylation of minaprine to 4-hydroxyminaprine.

Chemical IUPAC Name

4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine

Chemical Formula

C17H22N4O

Organisms Affected

Humans and other mammals