Biotrakson: Full Drug Profile
Biotrakson - General Information
A broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.
Pharmacology of Biotrakson
Biotrakson is a cephalosporin/cephamycin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. Biotrakson has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Biotrakson results from the inhibition of cell wall synthesis and is mediated through Biotrakson binding to penicillin binding proteins (PBPs). Biotrakson is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.
Biotrakson for patients
Patient Information:
Patients should be counseled that antibacterial drugs including Ceftriaxone should only be used to
treat bacterial infections. They do not treat viral infections (eg, common cold). When Ceftriaxone
is prescribed to treat a bacterial infection, patients should be told that although it is common
to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of
the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and
will not be treatable by Ceftriaxone or other antibacterial drugs in the future.
Biotrakson Interactions
No information provided.
Biotrakson Contraindications
Rocephin is contraindicated in patients with known allergy to the cephalosporin class of antibiotics.
Additional information about Biotrakson
Biotrakson Indication: For the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph Mechanism Of Action: Biotrakson works by inhibiting the mucopeptide synthesis in the bacterial cell wall. The beta-lactam moiety of Biotrakson binds to carboxypeptidases, endopeptidases, and transpeptidases in the bacterial cytoplasmic membrane. These enzymes are involved in cell-wall synthesis and cell division. By binding to these enzymes, Biotrakson results in the formation of of defective cell walls and cell death. Drug Interactions: Amikacin Increased risk of nephrotoxicity Gentamicin Increased risk of nephrotoxicity Anisindione The cephalosporin increases the anticoagulant effect Dicumarol The cephalosporin increases the anticoagulant effect Acenocoumarol The cephalosporin increases the anticoagulant effect Warfarin The cephalosporin increases the anticoagulant effect Kanamycin Increased risk of nephrotoxicity Neomycin Increased risk of nephrotoxicity Netilmicin Increased risk of nephrotoxicity Streptomycin Increased risk of nephrotoxicity Tobramycin Increased risk of nephrotoxicity Food Interactions: Not Available Generic Name: Ceftriaxone Synonyms: Ceftriaxona [Inn-Spanish]; Ceftriaxonum [Inn-Latin]; Cefatriaxone; Ceftriazone Drug Category: Anti-Bacterial Agents; Cephalosporins Drug Type: Small Molecule; Approved Other Brand Names containing Ceftriaxone: Biotrakson; Rocephine; Absorption: Not Available Toxicity (Overdose): Not Available Protein Binding: 95% Biotransformation: Not Available Half Life: 5.8-8.7 hours Dosage Forms of Biotrakson: Powder, for solution Intravenous Chemical IUPAC Name: (6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(2-methyl-5,6-dioxo-1H-1,2,4-triazin-3-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical Formula: C18H18N8O7S3 Ceftriaxone on Wikipedia: https://en.wikipedia.org/wiki/Ceftriaxone Organisms Affected: Enteric bacteria and other eubacteria