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Apo-flunarizine capsules: Full Drug Profile

Medically reviewed by Dr. Otari Nergadze, Neurosurgeon | Updated: January 2026

Apo-flunarizine capsules - General Information

Apo-flunarizine capsules is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

 

Pharmacology of Apo-flunarizine capsules

Apo-flunarizine capsules is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity.

 

Additional information about Apo-flunarizine capsules

Apo-flunarizine capsules Indication

Used in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy.

Food Interactions
Take without regard to meals.
Generic Name
Flunarizine
Synonyms
Flunarizinum [inn-latin]; Flunarizina [inn-spanish]; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine; (E)-1-[Bis-(p-fluorophenyl)methyl]-4-cinnamylpiperazine; Flunarizine Hydrochloride; flunarizine dihydrochloride
Drug Category
Anticonvulsants; Calcium Channel Blockers; Histamine H1 Antagonists; Vasodilator Agents
Drug Type
Small Molecule; Approved
Other Brand Names containing Flunarizine
Sibelium; Novo-Flunarizine; Apo-flunarizine capsules; Vertix; Zinasen; Issium; Fluvert; Flufenal;
Absorption
85% following oral administration.
Protein Binding
99% bound to plasma proteins
Biotransformation
Hepatic, to two metabolites via N-dealylation and hydroxylation.
Half Life
18 days
Dosage Forms of Apo-flunarizine capsules
Capsule Oral
Chemical IUPAC Name
1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine
Chemical Formula
C26H26F2N2
Organisms Affected
Humans and other mammals