Apo-Tenoxicam: Full Drug Profile

Apo-Tenoxicam - General Information

Apo-Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Pharmacology of Apo-Tenoxicam

Apo-Tenoxicam, an antiinflammatory agent with analgesic and antipyretic properties, is used to treat osteoarthritis and control acute pain.

Additional information about Apo-Tenoxicam

Apo-Tenoxicam Indication

For the treatment of rheumatoid arthritis, osteoarthritis, backache, and pain.

Mechanism Of Action

The antiinflammatory effects of tenoxicam may result from the inhibition of the enzyme cycooxygenase and the subsequent peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, their inhibition accounts for the peripheral analgesic effects of tenoxicam. Antipyresis may occur by central action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat loss.

Generic Name

Tenoxicam

Drug Category

Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors

Drug Type

Small Molecule; Approved

Other Brand Names containing Tenoxicam

Apo-Tenoxicam; Novo-Tenoxicam; Tenoxicam [Usan-Ban-Inn-Jan]; Tenoxicamum [Inn-Latin]; Tilcotil;

Absorption

Oral absorption of tenoxicam is rapid and complete (absolute bioavailability 100%).

Protein Binding

99%

Biotransformation

Tenoxicam is metabolized in the liver to several pharmacologically inactive metabolites (mainly 5'-hydroxy-tenoxicam).

Half Life

72 hours (range 59 to 74 hours)

Dosage Forms of Apo-Tenoxicam

Tablet Oral

Chemical IUPAC Name

(3Z)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxothieno[2,3-e]thiazin-4-one

Chemical Formula

C13H11N3O4S2

Organisms Affected

Humans and other mammals