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Apo-Folic: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Apo-Folic - General Information

A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

 

Pharmacology of Apo-Folic

Folic acid, a water-soluble B-complex vitamin, is found in foods such as liver, kidneys, yeast, and leafy, green vegetables. Folic acid is used to diagnose folate deficiency and to treat topical sprue and megaloblastic and macrocytic anemias, hematologic complications resulting from a deficiency in folic acid.

 

Apo-Folic for patients

 

Apo-Folic Interactions

Medications that interfere with your body's ability to use folate may also increase the need for this vitamin. Medications can interfere with folate utilization, including: anticonvulsant medications (such as phenytoin, and primidone) metformin (sometimes prescribed to control blood sugar in type 2 diabetes) sulfasalazine (used to control inflammation associated with Crohn's disease and ulcerative colitis) triamterene (a diuretic) Methotrexate There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (�g, sometimes mcg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency. It is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.

 

Apo-Folic Contraindications

 

Additional information about Apo-Folic

Apo-Folic Indication: For treatment of folic acid deficiency, megaloblastic anemia and in anemias of nutritional supplements, pregnancy, infancy, or childhood. Mechanism Of Action: Folic acid, as it is biochemically inactive, is converted to tetrahydrofolic acid and methyltetrahydrofolate by dihydrofolate reductase. These folic acid congeners are transported across cells by receptor-mediated endocytosis where they are needed to maintain normal erythropoiesis, synthesize purine and thymidylate nucleic acids, interconvert amino acids, methylate tRNA, and generate and use formate. Using vitamin B12 as a cofactor, folic acid can normalize high homocysteine levels by remethylation of homocysteine to methionine via methionine synthetase. Drug Interactions: Ethotoin Folic acid decreases the levels of hydantoin Fosphenytoin Folic acid decreases the levels of hydantoin Mephenytoin Folic acid decreases the levels of hydantoin Phenytoin Folic acid decreases the levels of hydantoin Amobarbital Folic acid decreases the effect of anticonvulsant Aprobarbital Folic acid decreases the effect of anticonvulsant Butabarbital Folic acid decreases the effect of anticonvulsant Butalbital Folic acid decreases the effect of anticonvulsant Butethal Folic acid decreases the effect of anticonvulsant Dihydroquinidine barbiturate Folic acid decreases the effect of anticonvulsant Heptabarbital Folic acid decreases the effect of anticonvulsant Hexobarbital Folic acid decreases the effect of anticonvulsant Methohexital Folic acid decreases the effect of anticonvulsant Methylphenobarbital Folic acid decreases the effect of anticonvulsant Pentobarbital Folic acid decreases the effect of anticonvulsant Phenobarbital Folic acid decreases the effect of anticonvulsant Primidone Folic acid decreases the effect of anticonvulsant Quinidine barbiturate Folic acid decreases the effect of anticonvulsant Secobarbital Folic acid decreases the effect of anticonvulsant Talbutal Folic acid decreases the effect of anticonvulsant Food Interactions: Not Available Generic Name: Folic Acid Synonyms: Folate; PGA; Pteroyl-L-glutamic acid; Pteroyl-L-monoglutamic acid; Pteroylglutamic acid; Pteroylmonoglutamic acid; Vitamin M; Vitamin Be; Vitamin Bc; Vitamin B9 Drug Category: Dietary supplement; Micronutrient Drug Type: Small Molecule; Nutraceutical; Approved Other Brand Names containing Folic Acid: Acifolic; Apo-Folic; Cytofol; Dosfolat B activ; Folacid; Folacin; Folbal; Folcidin; Foldine; Folettes; Foliamin; Folicet; Folipac; Folsan; Folsaure; Folsav; Folvite; Folvron; Incafolic; Millafol; Absorption: Not Available Toxicity (Overdose): IPR-MUS LD50 85 mg/kg,IVN-GPG LD50 120 mg/kg, IVN-MUS LD50 239 mg/kg, IVN-RAT LD50 500 mg/kg, IVN-RBT LD50 410 mg/kg Protein Binding: Very high to plasma protein Biotransformation: Hepatic Half Life: Not Available Dosage Forms of Apo-Folic: Liquid Intravenous Tablet Oral Capsule Oral Chemical IUPAC Name: (2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid Chemical Formula: C19H19N7O6 Folic Acid on Wikipedia: https://en.wikipedia.org/wiki/Folic_Acid Organisms Affected: Humans and other mammals