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Actilin: Full Drug Profile

Medically reviewed by Min Clinic Staff | Updated: January 2026

Actilin - General Information

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)

 

Pharmacology of Actilin

Actilin is used for the treatment of bacterial eye infections such as conjunctivitis. Actilin is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Actilin works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Actilin is useful primarily in infections involving aerobic bacteria bacteria.

 

Additional information about Actilin

Actilin Indication

For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal

Mechanism Of Action
Actilin binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Generic Name
Framycetin
Synonyms
Framycetinum [Inn-Latin]; Neomycin B; Streptothricin B
Drug Category
Anti-Bacterial Agents; Antibiotics
Drug Type
Small Molecule; Approved
Other Brand Names containing Framycetin
Actilin; Actiline; Antibiotique; Dekamycin V; Enterfram; Fradiomycin B; Framygen; Nebramycin X; Negamicin; Neomycin A; Soframycin; Soframycin Ophthalmic; Soframycine;
Dosage Forms of Actilin
Solution / drops Ophthalmic
Chemical IUPAC Name
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
Chemical Formula
C23H46N6O13
Organisms Affected
Enteric bacteria and other eubacteria